CALL FOR PAPERS Cigarette Smoke-Induced Lung Endothelial and Alveolar Epithelial Injury Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice
نویسندگان
چکیده
Laszlo Farkas, Daniela Farkas, David Warburton, Jack Gauldie, Wei Shi, Martin R. Stampfli, Norbert F. Voelkel, and Martin Kolb Departments of Medicine, Pathology, and Molecular Medicine, McMaster University, Hamilton; Firestone Institute for Respiratory Health, St. Joseph’s Healthcare, Hamilton, Ontario, Canada; Virginia Commonwealth University, Richmond, Virginia; and The Saban Institute, Developmental Biology Program, Los Angeles Children’s Hospital, Los Angeles, California
منابع مشابه
Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice.
The concept of genetic susceptibility factors predisposing cigarette smokers to develop emphysema stems from the clinical observation that only a fraction of smokers develop clinically significant chronic obstructive pulmonary disease. We investigated whether Smad3 knockout mice, which develop spontaneous air space enlargement after birth because of a defect in transforming growth factor-β (TGF...
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Cigarette smoking is a major risk factor in the development of various lung diseases, including pulmonary emphysema, pulmonary fibrosis, and lung cancer. The mechanisms of these diseases include alterations in alveolar epithelial cells, which are essential in the maintenance of normal alveolar architecture and function. Following cigarette smoking, alterations in alveolar epithelial cells induc...
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Emphysema is characterized by enlargement of the distal airspaces in the lungs due to destruction of alveolar walls. Alveolar endothelial and epithelial cell apoptosis induced by cigarette smoke is thought to be a possible mechanism for this cell loss. In contrast, our studies show that cigarette smoke condensate (CSC) induces necrosis in alveolar epithelial cells and human umbilical vein endot...
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